Category: Sickle cell disease
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Prophylactic red blood cell matching in patients with sickle cell disease (SCD) and transfusion-dependent thalassemia (TDT)
The January 2025 issue of the British Journal of Haematology (BJHAEM) published an updated evidence-based guideline for red blood cell antigen matching in patients with hemoglobinopathies.1 Alloimmunization to red blood cell antigens has been linked to patient morbidity and mortality in patients with sickle cell disease (SCD) and transfusion-dependent thalassemia (TDT). The practice of transfusing…
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Biotin-labeled red cell survival in pediatric patients with sickle cell disease who form antibodies of uncertain clinical significance
Patients of all ages with sickle cell disease (SCD) who are frequently transfused develop more auto- and alloantibodies against RBC antigens compared to the general population of transfused patients.[1] [2] In addition, chronically transfused children, compared to those who are infrequently transfused, are over three times more likely to develop warm autoantibodies (WAA),[3] which are…
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Sickle Cell Awareness Month: How the American Red Cross Mission is Meeting the Need
September is National Sickle Cell Awareness Month, a time dedicated to raising awareness about sickle cell disease and its devastating impact on individuals and families. While sickle cell disease is the most common genetic blood disease in the U.S., occurring in 1 in 365 Black or African American births, limited healthcare resources have historically been…
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SCD in the Era of COVID
Patients with SCD (Sickle Cell Disease) are more likely to have a severe COVID-19 disease course and a higher case-fatality rate in contrast to the general population. RBC (Red Blood Cell) transfusions are commonly given to patients with SCD and COVID-19. Hyperhemolysis syndrome (HHS) is an infrequent, severe hemolytic transfusion reaction primarily been described in…