Category: Platelet
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Cold-Stored Platelets and Room Temperature Platelets
With the introduction of cold-stored platelets (CSP) into practice, transfusion services have encountered challenges in interpreting FDA guidance. The FDA indicates that CSP may be used to treat active bleeding when conventional platelets—room temperature platelets (RTP)—are unavailable or impractical to use.1 In addition, the FDA requires transfusion services to develop standard operating procedures (SOPs) that…
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Does Pathogen Reduction Impair Platelet Function In Actively Bleeding Patients?
The initial FDA approval for pathogen-reduced (PR) platelets was supported by data from the SPRINT trial1,2 showing PR platelets to be noninferior to control platelets with respect to the incidence of bleeding after transfusion to thrombocytopenic patients; only about 16% of whom had clinically significant bleeding on study entry. Are PR platelets as effective as…
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Are ABO-Identical Platelet Transfusions Better?
Platelets express numerous surface antigens including A, B, and H; and the plasma in which they are suspended contain the corresponding donor isohemagglutinins (antibodies to A or B antigen). Transfusion of incompatible platelets may result in hemolysis. However, because the risk is low, the practice of providing ABO-nonidentical (ABON) or ABO-identical (ABOI) platelets to patients…
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Cold-Stored Platelets
Cold-stored platelets (CSP) are a recent hot topic. Prior to the 1960s, refrigerated whole blood contained red cells, plasma, white cells and (cold-stored) platelets transfused as one product to bleeding patients. With broad advancement in medical treatments and manufacturing technology, transfusion therapy became component-based whereby a single donation could yield specific blood products for multiple…
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How to Manage Blood Product Shortages
The December 2023 issue of the journal Transfusion has a “How do I do it” article on how to manage blood product shortages.i The article was authored by the AABB Donor and Blood Component Management Subsection members with the participation of blood center and blood bank staff members performing blood donor recruitment, blood collection, patient…
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Young Apheresis Platelet Donors Give Hope To The Resiliency Of The US Platelet Supply
Summary provided by Dr. Baia Lasky Platelet demand continues to increase (1) and U.S. hospitals face frequent shortages (2). Between 2010 and 2019, the American Red Cross’ (ARC) platelet distributions increased by 16.6% (778,775 to 907,851 units); therefore, a reliable and sustainable apheresis platelet donor (APD) base is essential to support patient care. . During…